Why is Blood Volume Analysis Important?

The Smallest Volume is the Most Vital for Survival

It is crucial to differentiate between interstitial overload and intravascular overload. The BVA-100 blood test directly quantifies the intravascular blood, plasma and red cell giving you actionable information you need to achieve optimal fluid management.

Interstital: 11-13 L | Intracellular: 27-30 L | Intravascular: 3.0-3.5 L

Heterogeneity in Total Blood Volume & Red Blood Cell Volume
Status is Common - Once Size Treatment Does Not Fit All

Frequency Distribution of Quantitated Volume

Deficit/Excess at Admission (n = 50)

The extent, composition, and distribution of volume overload in decompensated heart failure are highly variable, and this variability needs to be taken into account in the approach to individualized therapy.

Wayne L. Miller, M.D., Mayo Clinic

Managing Volume Derangement is a Challenge with High Stakes

The Goal: Get the Patient to Their Optimal Blood Volume

Indirect Measures Offer Low Clinical Utility as Indicators of
True Intravascular Volume Status

Clinical signs and symptoms typically describe fluid predominantly in the interstitial compartment. Hemodynamics, biomarkers and other common indirect measures can be costly, invasive, and are neither sensitive nor specific indicators of actual intravascular volume status.

Pressure is Not Volume – Volume is Not Pressure

Neither CVP, PCWP, nor dPAP accurately reflect intravascular volume status. Quantitative blood volume measurement (BVA) and cardiac hemodynamics provide complementary but different information.

Is the increase in pressure due to vasconstriction or volume expansion?

Patient with the Same Hct May Be Highly Discordant
in True Red Blood Cell Volume Status

The BVA is a method that provides an accurate measure of actual blood volume and gives researchers and clinicians the opportunity to measure the blood volume as opposed to estimate it. Our research essentially shows that reliance on surrogate markers of volume could be problematic. This provides an avenue to better understand our approach to patients with heart failure.

Marat Fudim, M.D., Duke University

BVA-100 Test Solution

Hospitals and clinicians struggle with readmissions, mortality and wasted resources. The BVA-100 test provides clinicians with accurate, actionable data to optimize treatment plans and individualize care improving outcomes and reducing duration and cost of care.

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