Blood Volume Measurements Improved Survival

Prospective randomized control trial in Surgical ICU

N=100

  66% reduction in mortality

  20% reduction in LOS

  36 hour earlier treatment decisions

  44% change in treatment strategy

“An important aspect of care was the earlier treatment of intravascular volume deviations in the BVA group, before the abnormality became clinically manifested.”

Mihae Yu, M.D. – Queens Hospital

66% reduction in mortality

44% change in treatment strategy

Blood Volume Measurements Improved Survival

Prospective randomized control in which 100 critically ill surgical patients with septic shock, sever sepsis, severe respiratory failure, and/or cardiovascular collapse were evaluated. Mean APACHE II scores were comparable across both study arms, at 25 (BVA=50) vs. 24 (conventional, n=50) (p=0.16). All patients underwent BVA testing; physicians were blinded to BVA results for the control group, which was conventionally managed by pulmonary artery catheter (PAC).

   Hypervolemia present in 48% control vs. 37% BVA

   RBC deficiency present in 33% control vs. 16% BVA

   Control group mean delay in transfusion of 1.5 ± 2 days

   PAC did not reliably correlate with volume

66% reduction in mortality

For the BVA group, 44% of test results led to a change in treatment strategy

“An important aspect of care was the earlier treatment of intravascular volume deviations in the BVA group, before the abnormality became clinically manifested.”

Mihae Yu, M.D. – Queens Hospital

Unique Measure of Capillary Permeability with BVA-100

Retrospective study in Surgical ICU

N = 164

Usage of BVA-100 predictive of reduced mortality and length of stay


Civetta, Taylor, & Kirby’s Critical Care, Fourth Edition 2009