Prospective randomized control in which 100 critically ill surgical patients with septic shock, sever sepsis, severe respiratory failure, and/or cardiovascular collapse were evaluated. Mean APACHE II scores were comparable across both study arms, at 25 (BVA=50) vs. 24 (conventional, n=50) (p=0.16). All patients underwent BVA testing; physicians were blinded to BVA results for the control group, which was conventionally managed by pulmonary artery catheter (PAC).

   Hypervolemia present in 48% control vs. 37% BVA

   RBC deficiency present in 33% control vs. 16% BVA

   Control group mean delay in transfusion of 1.5 ± 2 days

   PAC did not reliably correlate with volume

“An important aspect of care was the earlier treatment of intravascular volume deviations in the BVA group, before the abnormality became clinically manifested.”

Mihae Yu, M.D. – Queens Hospital