Cardiology

• In Search of Euvolemia in Heart Failure
• Anemic Patients with HFNEF Have a Reduced Red Cell Volume, True Anemia and Concomitant Plasma Volume Expansion
• Blood Volume Analysis Coupled with Ultrafiltration in the Management of Congestive Heart Failure Guided Therapy to Achieve Euvolemia
• Blood Volume and Brain Natriuretic Peptide in Congestive Heart Failure: A Pilot Study
• Blood Volume Assessment in the Diagnosis and Treatment of Chronic Heart Failure
• Blood Volume Measurements in Patients With Heart Failure and a Preserved Ejection Fraction: Implications for Diagnosing Anemia
• Circulating Blood Volume Measurements Correlate Poorly with Pulmonary Artery Catheter Measurements
• Comparison of Blood Volume Characteristics in Anemic Patients With Low Versus Preserved Left Ventricular Ejection Fractions
• Early Versus Late Postural Tachycardia: A Re-evaluation of a Syndrome
• Effect of Erythropoietin on Exercise Capacity in Patients with Moderate to Severe Chronic Heart Failure
• Hemodilution is Common in Patients with Advanced Heart Failure
• The Importance of Correct Norms in Blood Volume Measurement
• Measurement of Blood Volume at Bedside: New Era in Critical Care Medicine
• Plasma Catecholamines and Blood Volume in Native Andeans During Hypoxia and Normoxia
• Plasma Volume and Outcome in Pulmonary Hypertension
• Postural Pseudoanemia: Posture-Dependent Change in Hematocrit
• Relation of Unrecognized Hypervolemia in Chronic Heart Failure to Clinical Status, Hemodynamics, and Patient Outcomes
• Researchers Probe Anemia Heart Failure Link
• Techniques Used for the Determination of Blood Volume
• Treatment of Anemia in Patients with Chronic Heart Failure
• Unrecognized Volume Overload in Congestive Heart Failure
• A Word Salad in the Treatment of CHF: BVA, ICG, BNP

Clinical Evidence Nuclear Medicine

• Blood Volume Analysis: A New Technique and New Clinical Interest Reinvigorate a Classic Study
• Blood Volume Determination, A Nuclear Medicine Test in Evolution
• Comparison of Red Cell and Whole Blood Volume as Performed Using Both Chromium-51-Tagged Red Cells and Iodine-125-Tagged Albumin and Using I-131-Tagged Albumin and Extrapolated Red Cell Volume

Clinical Evidence Hypertension and Syncope

• Correlation of Quantitated Intravascular Volume with Blood Pressure in Patients with Systemic Hypertension
• Blood Volume Measurement as a Tool in Diagnosing Syncope
• Blood Volume Measurements in Hypertensive Disease
• Renin-Aldosterone Paradox and Perturbed Blood Volume Regulation Underlying Postural Tachycardia Syndrome

Clinical Evidence Intensive and Critical Care Medicine

• The Availability of Circulating Blood Volume Values Alters Fluid Management in Critically Ill Surgical Patients
• Blood Volume Analysis Can Distinguish True Anemia from Hemodilution in Critically Ill Patients
• Blood Volume Measurements: Impact on Fluid Management
• Correlation of Blood Volume Values and Pulmonary Artery Catheter Measurements
• A Prospective Randomized Trial Using Blood Volume Analysis in Addition to Pulmonary Artery Catheter, Compared with Pulmonary Artery Catheter Alone, to Guide Shock Resuscitation in Critically Ill Surgical Patients
• Would Hypovolemia Be an Advantage or Disadvantage in the Management of Critically Ill Patients with Septic Shock?
• Would the Blood Volume Analyzer (BVA-100) Be an Alternative to Pulmonary Artery Catheter (PAC) in Critically Ill Patients (abstract)

Clinical Evidence Surgery and Anesthesiology

• Peripheral Blood Hematocrit in Critically Ill Surgical Patients: An Imprecise Surrogate of True Red Blood Cell Volume
• Measurement of Blood Volume Benefits Critically Ill Patients
• Preoperative Blood Volume Deficit Influences Blood Transfusion Requirement in Females and Males Undergoing Coronary Bypass Graft Surgery

Chronic Fatigue Syndrome

• Blood Volume Status in Patients with Chronic Fatigue Syndrome: Relation to Complaints

• Society of Critical Care Congress 2021: A Quantitative Analysis of Clinical End Points of Resuscitation After Massive Blood Transfusions
• Society of Critical Care Congress 2019: Peripheral Blood Hematocrit is an Inaccurate Index of Red Cell Volume in Critically Ill Subjects
• Society of Critical Care Congress 2019: End Points of Resuscitation: Inaccurate Estimates of Intravascular Volume in Surgical Subjects?
• Society of Critical Care Congress 2019: Reducing Blood Sampling for Circulating Blood Volume Determination: A Pilot Feasibility Analysis
• Heart Failure Society of America 2018: Volume Kidney Interaction in Chronic Heart Failure: Impact of Subclinical Volume Expansion and Chronic Kidney Disease on Clinical Outcomes
• Heart Failure Society of America 2018: Volume and Pressure in Heart Failure: Complementary, But Not Two Sides of the Same Coin
• American Society of Nephrology 2008: Accuracy of Anemia Evaluation Is Improved in Acutely and Chronically Ill Patients by Accounting for Volume Status (Pillon et al.)
• American Society of Nephrology 2012: Radioisotope Blood Volume Measurement in Hemodialysis Patients (Park et al.)
• Heart Failure Society of America 2006: The Administration of Subcutaneous Erythropoietin in Elderly Patients with Heart Failure and Normal Ejection Fraction Over Three Months Is Safe and Effective (Cohen et al.)
• Heart Failure Society of America 2010: Racial Differences in Blood Volumes in Patients with Heart Failure and a Preserved Ejection Fraction (HFPEF): Implications for Diagnosing Anemia (Noumi et al.)
  Lack of Correlation between I-131 Labeled Albumin Measurements of Blood Volume and Serum B-Natiuretic Peptide Levels in Heart Failure Patients (Strobeck and Giordano)
• Heart Failure Society of America 2012: Masked Polycythemia in Patients with Heart Failure and a Preserved Ejection Fraction: an Underappreciated Phenotype? (Ramnauth et al.)
• Heart Failure Society of America 2013: Volume Overload and Quantitated Blood-Plasma Volume: How Effective is Intravenous Diuretic Therapy in Patients Hospitalized for Decompensated Chronic Heart Failure?
• National Kidney Foundation 2009: Peripheral Blood Hematocrit is a Poor Surrogate for Red Blood Cell Volume in Patients with Volume Excess or Depletion (Pillon et al.)
• Society of Cardiovascular Anesthesiologists 2010: Red Cell Mass Is Not Well Conserved Following Elective Cardiac Surgery Despite Use of Cell Salvage and Transfusion Guided by Peripheral Hematocrit (Nelson et al.)
  Patients Are Not Normovolemic Following Cardiac Surgery Despite Concerted Efforts to Manage Fluid and Volume Status (Nelson et al.)
• Society of Critical Care Medicine 2006: Correlation between Blood Volume and Pulmonary Artery Catheter Measurements (Yamauchi et al.)
• Society of Critical Care Medicine 2007: Does Blood Volume and Brain Natriuretic Peptide (BNP) Correlate? (Apte et al.)
  Does Hematocrit Reflect Red Cell Volume When Adjusted for Plasma Volume? (Edwards et al.)
• Society of Critical Care Medicine 2008: Right Ventricular End Diastolic Volume (RVEDVI) and Brain Natriuretic Peptide (BNP) May Not Reflect Volume Status in the Critically Ill Patient (Moran et al.)
  Stroke Volume Variation as a Marker of Intravascular Volume Compared to Blood Volume Measurement (Pei et al.)
• Society of Critical Care Medicine 2009: A Comparison of Pulse Pressure Variation and Blood Volume Measurement (Domingo et al.)
• Society of Critical Care Medicine 2010: Activated Protein C and Corticosteroids Decrease the Rate of Albumin Transudation in Septic Shock (Hayashi et al.)
  A Comparison of Pulse Pressure and Blood Volume Measurement (Domingo et al.)
  Elevated Transcapillary Albumin Escape: A Marker of Increased Mortality (Inouye et al.)
  A Prospective Randomized Trial Using Blood Volume Analysis vs. Pulmonary Artery Catheter Measurements to Guide Fluid and Red Cell Management (Mihae Yu et al.)
  The Relationship Between IVC Collapsibility Ratio and Measured Whole Blood Volume in Surgical Critical Care Patients (Sharon Moran et al.)
• Society of Critical Care Medicine 2011: Is There a Relationship between SOFA scores and Albumin Leak Rates as a Marker of Endothelial Dysfunction? (DeFrancesch et al.)
  A Comparative Study of Systolic Pressure Variation and Blood Volume Measurements (Furuta et al.)
• Society of Critical Care Medicine 2012: Comparison of Blood Volume Analysis Measured by Ultrasound Dilution Method and Radioisotope Dilution Technique (Furuta et al.)
  The Use of Transcapillary Albumin Leak Rate as an Early Marker in a LPS Induced Sepsis Model (Bandt et al.)
• Society of Critical Care Medicine 2013: Utilization of Blood Volume Analysis for Distinguishing Cerebral Salt Wasting from SIADH (Fulda, et al.)
  A Comparison of Non-Invasive Hemoglobin Measurements to Laboratory Hemoglobin and to Red Blood Cell Volume-derived Hemoglobin (Shifflette, et al.)
• Society of Nuclear Medicine Annual Meeting 2010: Poster: Normalized Hematocrit from Blood Volume Analysis Offers Enhanced Accuracy over Peripheral Hematocrit in Assessment of Red Blood Cell Volume (Manzone, Dam, Howard-Sachs)
  Abstract: Normalized Hematocrit from Blood Volume Analysis Offers Enhanced Accuracy over Peripheral Hematocrit in Assessment of Red Blood Cell Volume (Manzone, Dam, Howard-Sachs)
• Western Trauma Association Annual Meeting 2010: Abstract: Blood Volume Analysis Can Distinguish True Anemia From Hemodilution In Critically Ill Trauma Patients (Van et al.)
  Presentation slide deck: Blood Volume Analysis Can Distinguish True Anemia From Hemodilution In Critically Ill Trauma Patients (Van et al.)
• Society of Critical Care Medicine 2017: Capillary Albumin Transudation Rate and Outcome in Critically Ill Subjects

• Heart Failure Society of America 2016: 30-day Readmissions Associated with Persistent Congestion or Anemia at Discharge in the First Heart Failure (HF) Cohort (n=47) to Receive Blood Volume Analysis (BVA) at Lankenau Medical Center

Abstracts

• The Brooklyn Hospital Center/Cornell Medical College, Brooklyn, NY
• Long Island Jewish Medical Center
• Maimonides Medical Center, Brooklyn, New York

Additional References

• Civetta, Taylor, & Kirby’s Critical Care – 5th Edition – Chapter 27 – Blood Volume Measurement
• Adverse Cerebral Outcomes after Coronary-Artery Bypass Surgery
• Anemia Not Just an Innocent Bystander?
• Anemia as a Risk Factor for Cardiovascular Disease in the Artherosclerosis Risk in Communities (ARIC) Study
• Chronic Renal Failure after Transplantation of a Nonrenal Organ
• Commentary on Measurement of Blood Volume and Red Cell Mass: Re-examination of 51CR and 125I Methods
• Contracted Plasma and Blood Volume in Chronic Heart Failure
• Diuretics, Mortality, and Nonrecovery of Renal Function in Acute Renal Failure
• The Effect of Correction of Mild Anemia in Severe, Resistant Congestive Heart Failure Using Subcutaneous Erythropoietin and Intravenous Iron: A Randomized Controlled Study
• Errors of Measurement for Blood Volume Parameters: A Meta-Analysis
• The Growing Problem of Chronic Renal Failure after Transplantation of a Nonrenal Organ
• Heart Failure
• How Deadly is the Deadly Quartet?
• International Council for Standardization in Haemotology (ICSH) Recommendations for Surrogate Reference Method for PCV
• Is the Packed Cell Volume (PCV) Reliable?
• Longitudinal Assessment of Neurocognitive Function after Coronary- Artery Bypass Surgery
• Measurement of Blood Volume and Red Cell Mass: Re-examination of 51Cr and 125I Methods
• A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
• Pacemaker Therapy for Prevention of Syncope in Patients with Recurrent Severe Vasovagal Syncope
• Predicting Fluid Responsiveness in ICU Patients
• Prediction of the Normal Blood Volume. Relation of Blood Volume to Body Habitus
• Pulse Dye Densitometry: A Novel Bedside Monitor of Circulating Blood Volume
• Recommended Methods for Measurement of Red-Cell and Plasma Volume
• Reduced Kidney Function and Anemia as Risk Factor for Mortality in Patients with Left Ventricular Dysfunction
• The Regulation and Measurement of Plasma Volume in Heart Failure
• Selective Use of Diagnostic Tests in Patients with Syncope of Unknown Cause
• The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
• Simultaneous Measurement of Plasma Volume and Cell Mass in Polycythemia of High Altitude
• Syncope: Is a Diagnosis a Diagnosis?
• [Transfusion] Management Strategies
• The Use of Subcutaneous Erythropoietin of the Anemia of Severe, Resistant Congestive Heart Failure Improves Cardiac and Renal and Functional Cardiac Class, and Markedly Reduces Hospitalizations