In a large mixed (HFpEF/HFrEF) cohort (n=245), individualized management guided by BVA improved key outcomes vs 10:1 propensity score matched-controls:
Propensity-score control matching analysis was performed for 245 consecutive HF admissions to a community hospital (Sept 2007–Apr 2014, age 78±10 yrs, HFrEF 50%, Stage 4 CKD 30%). Total blood volume (TBV) and red blood cell volume (RBCV) were measured at admission by an I-131 labeled albumin indicator-dilution technique [Daxor BVA-100]. Decongestion strategy targeted TBV to 6%-8% above patient-specific norm. Anemia was corrected with iron, epoetin, and/or packed red blood cells. Controls derived from CMS data were matched 10:1 for demographics, comorbidity, and year of treatment.1
Volume and red blood cell status heterogeneity was high, suggesting a medical need for the direct, accurate evaluation only possible with BVA.
Points of contact in HF care at which to consider direct BVA
The extent, composition and distribution of volume overload in decompensated heart failure are highly variable, and this variability needs to be taken into account in the approach to individualized therapy.“2
- Wayne L.Miller, M.D.