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Recent Newsletters

• DAXOR Corporation Newsletter; Issue 1, March 2010

Recent Research Presentations

• American Society of Nephrology 2008

  • Accuracy of Anemia Evaluation Is Improved in Acutely and Chronically Ill Patients by Accounting for Volume Status (Pillon et al.)

• Heart Failure Society of America 2006

  • The Administration of Subcutaneous Erythropoietin in Elderly Patients with Heart Failure and Normal Ejection Fraction Over Three Months Is Safe and Effective (Cohen et al.)

• Heart Failure Society of America 2010

  • Racial Differences in Blood Volumes in Patients with Heart Failure and a Preserved Ejection Fraction (HFPEF): Implications for Diagnosing Anemia (Noumi et al.)
  • Lack of Correlation between I-131 Labeled Albumin Measurements of Blood Volume and Serum B-Natiuretic Peptide Levels in Heart Failure Patients (Strobeck and Giordano)

• National Kidney Foundation 2009

  • Peripheral Blood Hematocrit is a Poor Surrogate for Red Blood Cell Volume in Patients with Volume Excess or Depletion (Pillon et al.)

• Society of Cardiovascular Anesthesiologists 2010

  • Red Cell Mass Is Not Well Conserved Following Elective Cardiac Surgery Despite Use of Cell Salvage and Transfusion Guided by Peripheral Hematocrit (Nelson et al.)
  • Patients Are Not Normovolemic Following Cardiac Surgery Despite Concerted Efforts to Manage Fluid and Volume Status (Nelson et al.)

• Society of Critical Care Medicine 2006

  • Correlation between Blood Volume and Pulmonary Artery Catheter Measurements (Yamauchi et al.)

• Society of Critical Care Medicine 2007

  • Does Blood Volume and Brain Natriuretic Peptide (BNP) Correlate? (Apte et al.)
  • Does Hematocrit Reflect Red Cell Volume When Adjusted for Plasma Volume? (Edwards et al.)

• Society of Critical Care Medicine 2008

  • Right Ventricular End Diastolic Volume (RVEDVI) and Brain Natriuretic Peptide (BNP) May Not Reflect Volume Status in the Critically Ill Patient (Moran et al.)
  • Stroke Volume Variation as a Marker of Intravascular Volume Compared to Blood Volume Measurement (Pei et al.)

• Society of Critical Care Medicine 2009

  • A Comparison of Pulse Pressure Variation and Blood Volume Measurement (Domingo et al.)

• Society of Critical Care Medicine 2010

  • Activated Protein C and Corticosteroids Decrease the Rate of Albumin Transudation in Septic Shock (Hayashi et al.)
  • A Comparison of Pulse Pressure and Blood Volume Measurement (Domingo et al.)
  • Elevated Transcapillary Albumin Escape: A Marker of Increased Mortality (Inouye et al.)
  • A Prospective Randomized Trial Using Blood Volume Analysis vs. Pulmonary Artery Catheter Measurements to Guide Fluid and Red Cell Management (Mihae Yu et al.)
  • The Relationship Between IVC Collapsibility Ratio and Measured Whole Blood Volume in Surgical Critical Care Patients (Sharon Moran et al.)

• Society of Critical Care Medicine 2011

  • Is There a Relationship between SOFA scores and Albumin Leak Rates as a Marker of Endothelial Dysfunction? (DeFrancesch et al.)
  • A Comparative Study of Systolic Pressure Variation and Blood Volume Measurements (Furuta et al.)

• Society of Critical Care Medicine 2012

  • Comparison of Blood Volume Analysis Measured by Ultrasound Dilution Method and Radioisotope Dilution Technique (Furuta et al.)
  • The Use of Transcapillary Albumin Leak Rate as an Early Marker in a LPS Induced Sepsis Model (Bandt et al.)

• Society of Nuclear Medicine Annual Meeting 2010

  • Poster: "Normalized Hematocrit" from Blood Volume Analysis Offers Enhanced Accuracy over Peripheral Hematocrit in Assessment of Red Blood Cell Volume (Manzone, Dam, Howard-Sachs)
  • Abstract: "Normalized Hematocrit" from Blood Volume Analysis Offers Enhanced Accuracy over Peripheral Hematocrit in Assessment of Red Blood Cell Volume (Manzone, Dam, Howard-Sachs)

• Western Trauma Association Annual Meeting 2010

  • Abstract: Blood Volume Analysis Can Distinguish True Anemia From Hemodilution In Critically Ill Trauma Patients (Van et al.)
  • Presentation slide deck: Blood Volume Analysis Can Distinguish True Anemia From Hemodilution In Critically Ill Trauma Patients (Van et al.)

Clinical Evidence - Cardiology

• Anemic Patients with HFNEF Have a Reduced Red Cell Volume, True Anemia and Concomitant Plasma Volume Expansion

• Blood Volume Analysis Coupled with Ultrafiltration in the Management of Congestive Heart Failure - Guided Therapy to Achieve Euvolemia

• Blood Volume and Brain Natriuretic Peptide in Congestive Heart Failure: A Pilot Study

• Blood Volume Assessment in the Diagnosis and Treatment of Chronic Heart Failure

• Blood Volume Measurements in Patients With Heart Failure and a Preserved Ejection Fraction: Implications for Diagnosing Anemia

• Circulating Blood Volume Measurements Correlate Poorly with Pulmonary Artery Catheter Measurements

• Comparison of Blood Volume Characteristics in Anemic Patients With Low Versus Preserved Left Ventricular Ejection Fractions

• Early Versus Late Postural Tachycardia: A Re-evaluation of a Syndrome

• Effect of Erythropoietin on Exercise Capacity in Patients with Moderate to Severe Chronic Heart Failure

• Hemodilution is Common in Patients with Advanced Heart Failure

• The Importance of Correct Norms in Blood Volume Measurement

• Measurement of Blood Volume at Bedside: New Era in Critical Care Medicine

• Plasma Catecholamines and Blood Volume in Native Andeans During Hypoxia and Normoxia

• Plasma Volume and Outcome in Pulmonary Hypertension

• Postural Pseudoanemia: Posture-Dependent Change in Hematocrit

• Relation of Unrecognized Hypervolemia in Chronic Heart Failure to Clinical Status, Hemodynamics, and Patient Outcomes

• Researchers Probe Anemia - Heart Failure Link

• Techniques Used for the Determination of Blood Volume

• Treatment of Anemia in Patients with Chronic Heart Failure

• Unrecognized Volume Overload in Congestive Heart Failure

• A Word Salad in the Treatment of CHF: BVA, ICG, BNP

Clinical Evidence - Nuclear Medicine

• Blood Volume Analysis: A New Technique and New Clinical Interest Reinvigorate a Classic Study

• Comparison of Red Cell and Whole Blood Volume as Performed Using Both Chromium-51-Tagged Red Cells and Iodine-125-Tagged Albumin and Using I-131-Tagged Albumin and Extrapolated Red Cell Volume

Clinical Evidence - Hypertension and Syncope

• Blood Volume Measurement as a Tool in Diagnosing Syncope

• Blood Volume Measurements in Hypertensive Disease

• Renin-Aldosterone Paradox and Perturbed Blood Volume Regulation Underlying Postural Tachycardia Syndrome

Clinical Evidence - Intensive and Critical Care Medicine

• The Availability of Circulating Blood Volume Values Alters Fluid Management in Critically Ill Surgical Patients

• Blood Volume Analysis Can Distinguish True Anemia from Hemodilution in Critically Ill Patients

• Blood Volume Measurements: Impact on Fluid Management

• Blood Volume Measurements in Critical Care

• Correlation of Blood Volume Values and Pulmonary Artery Catheter Measurements

• A Prospective Randomized Trial Using Blood Volume Analysis in Addition to Pulmonary Artery Catheter, Compared with Pulmonary Artery Catheter Alone, to Guide Shock Resuscitation in Critically Ill Surgical Patients

• Would Hypovolemia Be an Advantage or Disadvantage in the Management of Critically Ill Patients with Septic Shock?

• Would the Blood Volume Analyzer (BVA-100) Be an Alternative to Pulmonary Artery Catheter (PAC) in Critically Ill Patients (abstract)

Clinical Evidence - CABG Surgery and Anesthesiology

• Peripheral Blood Hematocrit in Critically Ill Surgical Patients: An Imprecise Surrogate of True Red Blood Cell Volume

• Measurement of Blood Volume Benefits Critically Ill Patients

• Preoperative Blood Volume Deficit Influences Blood Transfusion Requirement in Females and Males Undergoing Coronary Bypass Graft Surgery

Abstracts

• The Brooklyn Hospital Center/Cornell Medical College, Brooklyn, NY

• Long Island Jewish Medical Center

• Maimonides Medical Center, Brooklyn, New York

Additional References

• Adverse Cerebral Outcomes after Coronary-Artery Bypass Surgery

• Anemia - Not Just an Innocent Bystander?

• Anemia as a Risk Factor for Cardiovascular Disease in the Artherosclerosis Risk in Communities (ARIC) Study

• Chronic Renal Failure after Transplantation of a Nonrenal Organ

• Commentary on Measurement of Blood Volume and Red Cell Mass: Re-examination of ⁵¹CR and ¹²⁵I Methods

• Contracted Plasma and Blood Volume in Chronic Heart Failure

• Diuretics, Mortality, and Nonrecovery of Renal Function in Acute Renal Failure

• The Effect of Correction of Mild Anemia in Severe, Resistant Congestive Heart Failure Using Subcutaneous Erythropoietin and Intravenous Iron: A Randomized Controlled Study

• Errors of Measurement for Blood Volume Parameters: A Meta-Analysis

• The Growing Problem of Chronic Renal Failure after Transplantation of a Nonrenal Organ

• Heart Failure

• How Deadly is the "Deadly Quartet"?

• International Council for Standardization in Haemotology (ICSH) Recommendations for "Surrogate" Reference Method for PCV

• Is the Packed Cell Volume (PCV) Reliable?

• Longitudinal Assessment of Neurocognitive Function after Coronary- Artery Bypass Surgery

• Measurement of Blood Volume and Red Cell Mass: Re-examination of ⁵¹Cr and ¹²⁵I Methods

• A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care

• Pacemaker Therapy for Prevention of Syncope in Patients with Recurrent Severe Vasovagal Syncope

• Predicting Fluid Responsiveness in ICU Patients

• Prediction of the Normal Blood Volume. Relation of Blood Volume to Body Habitus

• Pulse Dye Densitometry: A Novel Bedside Monitor of Circulating Blood Volume

• Recommended Methods for Measurement of Red-Cell and Plasma Volume

• Reduced Kidney Function and Anemia as Risk Factor for Mortality in Patients with Left Ventricular Dysfunction

• The Regulation and Measurement of Plasma Volume in Heart Failure

• Selective Use of Diagnostic Tests in Patients with Syncope of Unknown Cause

• The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

• Simultaneous Measurement of Plasma Volume and Cell Mass in Polycythemia of High Altitude

• Syncope: Is a Diagnosis a Diagnosis?

• [Transfusion] Management Strategies

• The Use of Subcutaneous Erythropoietin of the Anemia of Severe, Resistant Congestive Heart Failure Improves Cardiac and Renal and Functional Cardiac Class, and Markedly Reduces Hospitalizations